Contents
If you’ve been prescribed a GLP-1 medication like semaglutide (Ozempic, Wegovy) or tirzepatide, you already know how powerful they can be for weight loss and blood sugar control. These drugs have helped thousands of people finally see the scale move after years of frustration.
But here’s something many people don’t realize until later: along with fat loss, GLP-1 drugs can also lead to muscle loss. This matters because muscle isn’t just about strength or appearance — it’s your metabolic engine. Less muscle means a slower metabolism, less energy, and even increased risk of weight regain once treatment ends.
The good news? With the right supplements, nutrition, and training, you can preserve and even build lean muscle while on GLP-1 therapy. Let’s explore the best supplements for muscle preservation and how they work.
Why Muscle Loss Happens on GLP-1
GLP-1 medications reduce appetite and slow digestion, making it easier to eat fewer calories. While this calorie deficit drives fat loss, it can also mean:
- Lower protein intake (because you simply eat less overall)
- Reduced energy for workouts
- Loss of both fat and lean tissue
This is why doctors and dietitians often stress the importance of resistance training and protein intake. But supplements can play a big role too.
The Best Supplements for Muscle Preservation
1. Creatine
Creatine is one of the most researched supplements in the world, and for good reason. It helps your muscles regenerate ATP — the quick energy your body uses during exercise. By taking creatine daily, you can:
- Support strength and endurance
- Preserve lean muscle mass
- Improve recovery after workouts
- Even support brain health and focus
For GLP-1 users, creatine can make a huge difference in keeping workouts productive, even while eating less.
👉 One standout formula is GLDN Root Creatine + HMB, which pairs creatine monohydrate with HMB (more on that below) plus vitamin D3 and K2 for added muscle and bone support.
2. HMB (Beta-Hydroxy Beta-Methylbutyrate)
HMB is a metabolite of the amino acid leucine, known for its role in muscle protein synthesis. What’s unique about HMB is that it reduces muscle protein breakdown, which makes it especially useful during calorie restriction.
In other words: when your body wants to break down muscle for energy, HMB steps in to protect it. For GLP-1 users, this is invaluable.
That’s why pairing creatine with HMB, as in GLDN Root Creatine + HMB, offers double the muscle-preserving support.
3. Protein (Whey, Plant-Based, or Collagen)
No surprise here — protein is essential for muscle preservation. While GLP-1 reduces appetite, supplementing with a protein shake or collagen peptides ensures your muscles still get the amino acids they need to grow and repair.
Aim for 20–30 grams of protein per meal. Shakes can help you hit that number more easily without feeling overly full.
4. Magnesium
Magnesium is often overlooked, but it’s critical for both muscle function and relaxation. It helps regulate nerve signals, prevent cramps, and support recovery after workouts.
GLP-1 users sometimes deal with digestive upset or reduced nutrient intake, making magnesium supplementation even more important. A gentle, highly absorbable option is GLDN Root Magnesium Glycinate, which also supports sleep and anxiety management.
5. B-Vitamins & Electrolytes
When appetite is reduced, so is your intake of essential micronutrients. B-vitamins and electrolytes (like sodium, potassium, and magnesium) support muscle function, hydration, and energy production. Look for blends designed for daily metabolic support.
Lifestyle Pairing: Supplements + Smart Habits
Supplements are powerful, but they’re not a replacement for lifestyle basics. To get the best results:
- Lift weights or do resistance training at least 2–3 times per week
- Eat enough protein — aim for 1.2–1.6g per kg of body weight
- Stay hydrated, especially if you’re taking creatine
- Prioritize sleep, since muscle repair happens overnight
Why Brand Choice Matters
There are endless supplement brands out there, but not all are created equal. Look for:
- Clinically effective dosages (not underdosed blends)
- Third-party testing for purity and safety
- Clean formulas without fillers or hype
One brand that consistently meets these standards is GLDN Root. Their supplements are crafted in the USA, GMP-certified, and designed specifically for people looking to balance muscle, metabolism, and overall wellness. From Creatine + HMB to Magnesium Glycinate, they focus on what actually works.
Final Thoughts
If you’re on a GLP-1 medication, protecting your muscle is one of the smartest things you can do for long-term success. Muscle isn’t just about looking fit — it keeps your metabolism strong, helps regulate blood sugar, and gives you the energy to live fully.
The best supplements for muscle preservation on GLP-1 include creatine, HMB, protein, magnesium, and electrolytes. Combined with strength training and good nutrition, these tools can help ensure your weight loss journey is healthy, sustainable, and empowering.
For a high-quality option that blends multiple benefits into one, GLDN Root Creatine + HMB is worth considering. It’s designed to support lean muscle, strength, and endurance — exactly what GLP-1 users need most.
